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The Binding of Isaac Four Souls Requiem Expansion Amy the hot and unique BootThe Binding of Isaac: Four Souls Requiem is a huge expansion of the original Binding of Isaac: Four Souls game. Fight new monsters, collect new items, play as new characters. The expansion also adds new Solo and Multiplayer game modes and a brand new ROOM deck! The Room deck shakes up game play by adding global effects to all players that modify existing mechanics and even add new ones.